Pediatric Dermatology at the SID

251, Treatment interruption did not impact efficacy or long-term safety of dupilumab: A phase 3 open-label trial. Lisa Beck et al. International Psoriasis Council Symposium: Scientific and Clinical Advances in Psoriasis: 2017 and Beyond 12:00 pm – 1:30 pm B113-116 1:05 pm Abstract #190, Pediatric psoriasis is an independent risk factor for comorbidity development Megha Tollefson, MD Medical Dermatology Society at the Society For Investigative Dermatology 12:00 pm – 1:45 pm A105-106 12:05 pm Abstract #189, Psoriasis age of onset: Effect on treatment outcomes in the PSOLAR registry. Sanminder Singh 12:29 pm Abstract #656, Changes of lesional and non-lesional skin microbiome in the treatment course of atopic dermatitis. Jung-Im Na, PhD 1:16 pm Abstract #308, Bone marrow/cord blood transplantation (BMCBT) ameliorates symptoms in some, but not all, subtypes of severe generalized junctional epidermolysis bullosa Jakub Tolar, MD/PhD Concurrent Mini-Symposium 6 Clinical Research: Patient Outcomes Research 2:00 pm – 4:30 pm Oregon Ballroom 204 2:48 pm Abstract #334, Direct-access online care for the management of atopic dermatitis: A randomized controlled clinical trial examining patient quality of life. H. Kornmehl, S. Singh, M. Johnson and A. Armstrong. 3:24 pm Abstract #377, Type VII collagen (C7) expression and chimerism after bone marrow/cord blood transplantation (BMCBT) for severe generalized recessive dystrophic epidermolysis bullosa (RDEB). J. Tolar, J. McGrath, M. Osborn, D. Keene, M. Riddle, K. Hook, M. Hordinsky, M. Marinkovich, D. Woodley, M. Chen, R. Tryon, T. DeFor, C. Ebens, K. Tamai, A. Hovnanian, B. Blazar and J. Wagner. Concurrent Mini-Symosium 7 Genetic Disease, Gene Regulation and Gene Therapy 2:00 pm – 4:30 pm B113-116 2:00 pm Abstract #519, Phase I/IIa clinical trial for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes. Z. Siprashvili, N. Nguyen, E. Gorell, K. Loutit, Y. Dutt-Singkh, J. Nazaroff, P. Khuu, L. Furukawa, H. Lorenz, T. Leung, D. Keene, K. Rieger, PA. Khavari, A. Lane, JY. Tang and M. Marinkovich. 2:12 pm Abstract #493, Identification of a novel causative gene responsible for autosomal recessive congenital ichthyosis. Y. Shigehara, S. Okuda, R. Hayashi, H. Nakai, R. Abe, A. Ghani Kibbi, M. Kurban and Y. Shimomura. 2:24 pm Abstract #495, Ichthyosis molecular fingerprinting shows profound Th17skewing and a unique barrier gene expression pattern. H. He, T. Huynh, E. Ibler, K. Malik, G. Tran, H. Esaki, JG. Krueger, AS. Paller and E. Guttman-Yassky. 2:36 pm Abstract #474, Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. C. Feng, Z. Lin, S. Li, H. Wang, Y. Yang and X. Tan. 2:48 pm Abstract #514, Somatic mutations in nevus comedonicus identify nek9 as a determinant of follicular keratinocyte cell fate. J. Levinsohn, J. Sugarman, J. McNiff, I. Freiden, R. Antaya and K. Choate. 3:00 pm Abstract #513, GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activation. Y. Lim, A. Bacchiocchi, J. Qiu, A. Bruckner, L. Bercovitch, D. Narayan, J. McNiff, C. Ko, L. Robinson-Bostom, R. Antaya, R. Halaban and K. Choate. 3:12 pm Abstract #525, Determinants of intra-individual transcriptional homogeneity in inflammatory responses at anatomically separate sites. LC. Tsoi, J. Yang, Y. Liang, MK. Sarkar, X. Xing, MA. Beamer, A. Aphale, K. Raja, J. Kozlow, S. Getsios, JJ. Voorhees, JM. Kahlenberg, JT. Elder and JE. Gudjonsson. 3:24 pm Abstract #485, Genetic signature to assess risk of psoriasis subtypes through machine learning approach. MT. Patrick, PE. Stuart, K. Raja, JE. Gudjonsson, T. Tejasvi, JJ. Voorhees, DD. Gladman, RP. Nair, JT. Elder and LC. Tsoi. 3:36 pm Abstract #502, Sex bias in response to an NRF2 inducer in a pachyonychia congenita model. ML. Kerns, J. Hakim, A. Zieman and PA. Coulombe. 3:48 pm Abstract #492, SNPs within the MHC associated with atopic dermatitis are located within miRNA sequences. P. Clark, N. Chitnis, M. Kamoun, B. Johnson, DJ. Margolis and D. Monos. 4:00 pm Abstract #522, Integrative analysis of gene expression data and rare copy number variants in alopecia areata. L. Petukhova, AV. Patel, R. Severin, L. Bian, M. Verbitsky, S. Sanna-Cherchi, J. Cerise, A. Jabbari and AM. Christiano. 4:12 pm Abstract #501, Plasma PPi is the major, but not exclusive, cause of ectopic mineralization in pseudoxanthoma elasticum. J. Zhao, J. Kingman, J. Uitto and Q. Li. North American Hair ResearchSociety Scientific Meeting and Annual General Meeting 6:00 pm – 8:30 pm Oregon Ballroom 203 Abstract #494, Congenital generalized hypertrichosis with a copy number variation on chromosome 17q24. Hayashi Ryota, K. Yoshida, R. Abe, N. Yoshida and Y. Yoshida.494, Congenital generalized hypertrichosis with a copy number variation on chromosome 17q24. Hayashi Ryota, K. Yoshida, R. Abe, N. Yoshida and Y. Yoshida. Abstract #052, Identification of pathogenic T cell subsets in human alopecia areata. Annemieke du Jong, A. Jabbari, Z. Dai, L. Xing, D. Lee, V. Price, M. Duvic, D. Norris, M. Hordinsky, J. Mackay-Wiggan, R. Clynes and AM. Christiano.052, Identification of pathogenic T cell subsets in human alopecia areata. Annemieke du Jong, A. Jabbari, Z. Dai, L. Xing, D. Lee, V. Price, M. Duvic, D. Norris, M. Hordinsky, J. Mackay-Wiggan, R. Clynes and AM. Christiano. Abstract #712, A small molecule modulator of the wnt pathway (SM04554) as a potential topical treatment for androgenetic alopecia (AGA). Vishal Deshmukh, M. Pedraza, C. Barroga, J. Seykora and Y. Yazici.712, A small molecule modulator of the wnt pathway (SM04554) as a potential topical treatment for androgenetic alopecia (AGA). Vishal Deshmukh, M. Pedraza, C. Barroga, J. Seykora and Y. Yazici. Abstract #081, Analysis of the paired TCR alphaand beta-chains of single, intralesional CD8+T-cells in alopecia areata patients. Marta Bertolini, S. Altendorf, Y. Uchida, D. Below, R. Kelsch, Q. Zhou, A. Rossi, K. Dornmair and R. Paus.081, Analysis of the paired TCR alphaand beta-chains of single, intralesional CD8+T-cells in alopecia areata patients. Marta Bertolini, S. Altendorf, Y. Uchida, D. Below, R. Kelsch, Q. Zhou, A. Rossi, K. Dornmair and R. Paus. Saturday, April 29, 2017 Plenary Session III 8:00 am – 9:00 am Oregon Ballroom 201-202 Presiders: Ponciano Cruz, MD and Paul Nghiem, MD/PhD 8:00 am Abstract #299, Gentamicin therapy induced functional type VII collagen in recessive dystrophic epidermolysis bullosa patients harboring nonsense mutations. M. Chen, J. Cogan, Y. Hou, D. Keene and D. Woodley. 8:36 am Abstract #629, Staphylococcus aureus drives atopic dermatitis-like skin inflammation via IL-36-induced IL-17 responses. H. Liu, N. Archer, C. Dillen, Y. Wang, A. Ashbaugh, R. Ortines, S. Lee, R. Miller, M. Marchitto, G. Nunez and L. Miller. William Montagna Lecture 9:00 am – 9:30 am Oregon Ballroom 201-202 From Morphogenesis to Disease: A Wnt’ers Tale Sarah Millar, PhD Herman Beerman Lecture 9:30 am – 10:00 am Oregon Ballroom 201-202 How to Make Antibodies for Tumor Immunotherapy Alan J. Korman, PhD Clinical Scholars Program Session II Emerging Immunotherapies 10:15 am – 12:00 pm Oregon Ballroom 203 10:50 am Psoriasis – where are we and where are we heading Johann E. Gudjonsson, MD/PhD Concurrent Mini-Symposium 12 Clinical Research: Epidemiology of Skin Diseases 12:30 pm – 3:00 pm Oregon Ballroom 203 12:30 pm Abstract #216, A new mortality prediction tool for Stevens-Johnson syndrome/toxic epidermal necrolysis. RG. Micheletti and MH. Noe. 12:42 pm Abstract #164, Changes in the geographic distribution of atopic dermatitis on the body with age. TT. Schwartz, DJ. Margolis and K. Abuabara. 1:06 pm Abstract #198, Black children less likely to receive outpatient care for eczema than whites, but show signs of more severe disease: A cross-sectional analysis of the medical expenditure panel surveys. DB. Shin, AH. Fischer, DJ. Margolis and J. Takeshita. 2:06 pm Abstract #194, Decreasing prevalence of tanning bed use in the US: Data from the 2010, 2013, and 2015 National Health Surveys. AH. Fischer, S. Kang and A. Chien. 2:42 pm Abstract #213, Initial explorations into genotype-phenotype correlations in psoriasis: The homozygous recessive model. M. Milliken, B. Feng, K. Duffin and G. Krueger. Concurrent Mini-Symposium 13 Epidermal Structure and Barrier Function 12:30 pm – 3:00 pm Oregon Ballroom 204 2:42 pm Abstract #463, GJA1 mutations causing erythrokeratodermia variabilis et progressiva display increased connexin hemichannel activity. HM. Khan, L. Boyden, S. Tomita and K. Choate. Concurrent Mini-Symposium 14 Growth Factors, Cell Adhesion and Matrix Biology 12:30 pm – 3:00 pm C123-124 12:54 pm Abstract #544, A mutation in the desmoglein 1 transmembrane domain abrogates lipid raft targeting and causes severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome. J. Lewis, A. Caldara, N. Strong, JK. Wahl, AL. Mattheyses, M. Amagai, T. Sasaki, K. Nakabayashi, K. Hata, Y. Matsubara, A. Kubo, S. Stahley and A. Kowalczyk. Concurrent Mini-Symposium 15 Pharmacology and Drug Development 12:30 pm – 3:00 pm A105-106 12:42 pm Abstract #688, Efficacy of topical Vorinostat in the reversal of alopecia areata. E. Wang, JC. Chen and AM. Christiano. 2:30 pm Abstract #683, Induced DNA repair in xeroderma pigmentosum group C cells by readthrough of premature termination codons. R. Ono, S. Khan, C. Kuschal, D. Tamura, J. Chen, X. Luo, J. DiGiovanna and K. Kraemer.